Systole irana sp. n. and S. dzintari sp. n. are described from Iran. Systole complanata Zerova is recorded from Iran for the first time. These three Systole species belong to the subgenus Systole (Systole). The species of this subgenus have trophic associations with plants of family Apiaceae. An identification key to species of Systole from Iran is given. Holotype and paratypes of new species are deposited in the collection of I. I. Schmalhausen Institute of Zoology National Academy of Sciences of Ukraine (Kyiv).